GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs3760982 | 1 | rs11669175 | chr19:44289824 | ZNF155 | chr19:44488355-44502477:+ | -0.15 | -3.99 | 6.94E-5 | Breast cancer |
| BRCA | cis | rs3760982 | 1 | rs11669175 | chr19:44289824 | ZNF404 | chr19:44376516-44384288:- | -0.22 | -5.95 | 3.54E-9 | Breast cancer |
| BRCA | cis | rs4803468 | 1 | rs11670668 | chr19:41920454 | B3GNT8 | chr19:41931265-41934635:- | -0.24 | -7.29 | 6.01E-13 | Height |
| BRCA | cis | rs4803468 | 1 | rs11670757 | chr19:41913431 | B3GNT8 | chr19:41931265-41934635:- | -0.21 | -6.56 | 8.3E-11 | Height |
| BRCA | cis | rs11673344 | 1 | rs11673344 | chr19:37684966 | SIPA1L3 | chr19:38397868-38699006:+ | -0.13 | -3.66 | 0.000265 | Obesity-related traits |
| BRCA | cis | rs11673344 | 1 | rs11673344 | chr19:37684966 | ZNF568 | chr19:37407234-37488834:+ | -0.14 | -4.41 | 1.14E-5 | Obesity-related traits |
| BRCA | cis | rs11673344 | 1 | rs11673344 | chr19:37684966 | ZNF781 | chr19:38158650-38183216:- | -0.22 | -6.31 | 4.05E-10 | Obesity-related traits |
| BRCA | cis | rs11673344 | 1 | rs11673344 | chr19:37684966 | ZNF793 | chr19:37997841-38034237:+ | -0.2 | -5.68 | 1.73E-8 | Obesity-related traits |
| BRCA | cis | rs2243480 | 1 | rs1167613 | chr7:65487439 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 6.75 | 2.49E-11 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs1167613 | chr7:65487439 | LOC493754 | chr7:65993446-66057363:- | 0.2 | 3.4 | 0.000703 | Diabetic kidney disease |
| BRCA | cis | rs614226 | 1 | rs1167725 | chr12:120968559 | POP5 | chr12:121016849-121019201:- | -0.14 | -3.52 | 0.000444 | Type 1 diabetes nephropathy |
| BRCA | cis | rs614226 | 1 | rs1167726 | chr12:120967364 | GATC | chr12:120884284-120897761:+ | 0.13 | 3.63 | 0.000295 | Type 1 diabetes nephropathy |
| BRCA | cis | rs614226 | 1 | rs1167726 | chr12:120967364 | POP5 | chr12:121016849-121019201:- | 0.15 | 3.88 | 0.00011 | Type 1 diabetes nephropathy |
| BRCA | cis | rs614226 | 1 | rs1167727 | chr12:120965508 | GATC | chr12:120884284-120897761:+ | -0.13 | -3.38 | 0.000748 | Type 1 diabetes nephropathy |
| BRCA | cis | rs614226 | 1 | rs1167727 | chr12:120965508 | POP5 | chr12:121016849-121019201:- | -0.15 | -3.74 | 0.00019 | Type 1 diabetes nephropathy |